Glutamine Antagonist JHU-083 Normalizes Aberrant Hippocampal Glutaminase Activity and Improves Cognition in APOE4 Mice
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Glutamine and glutaminase in blood.
R.ECENTLY THE NEED of a method for the determination of glutamine and glutaminase in the blood and urine of humans led to the evaluation and adaptation of a single system for both. Methods of glutamine assay available depend on the determination of the ammonia liberated by mild hydrolysis with dilute hydrochloric, sulfuric, or trichioroacetic acid, or alkali, heat at neutral pH, or the action o...
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Diffusible factors, including netrins and semaphorins, are believed to be important cues for the formation of neural circuits in the forebrain. Here we have examined the role of netrin 1 in the development of hippocampal connections. We show that netrin 1 and its receptor, Dcc, are expressed in the developing fimbria and in projection neurons, respectively, and that netrin 1 promotes the outgro...
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The provision of glutamine in vivo has been observed to reduce to normal levels the neutrophilia observed after exhaustive exercise and to decrease the neutrophil chemoattractant, interleukin-8. Thus, the role for glutamine in the regulation of inflammatory mediators of human neutrophil activation was investigated. The study sought to establish whether glutamine supplementation in vitro affects...
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Storm-Mathisen, J. (1977) Brain Res. 120, 379-386 Storm-Mathisen, J. & Iversen, L. L. (1979) Neuroscience 4, 1237-1253 Storm-Mathisen, J. & Ottersen, 0. P. (1986) in Neurohisfochemistry: Modern Merhods and Applications (Panula, P., Paivarinta, H. & Soinila, S., eds.), pp. 107-136, Alan R. Liss, New York Storm-Mathisen, J. & Ottersen, 0. P. (1987) in Neurorransmiffers and Brain Function (Avoli, ...
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ژورنال
عنوان ژورنال: Journal of Alzheimer's Disease
سال: 2020
ISSN: 1387-2877,1875-8908
DOI: 10.3233/jad-190588